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Women using oral contraceptives should consider non-oral or barrier contraception for 4 weeks after initiating Mounjaro and after each dose increase, as advised in the Summary of Product Characteristics

This, in turn, may lead to the release of sulfur burps

Oral gavages are stressful, and there are likely differences in the uptake and metabolism between compounds administered orally (p.o.) and subcutaneously (s.c.), such as stimulation of gut hormones or altered first-pass metabolism

Mechanism designed to recapitulate naturally occurring PCSK9 loss-of-function, pointing to once-and-done editing as a potential alternative to chronic lipid-lowering therapy