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Mouse models lacking Parkin or PINK1 develop motor deficits and dopaminergic neuron loss when subjected to mitochondrial stress, particularly in combination with the mutator mouse model, which accumulates mtDNA mutations due to POlG dysfunction [60]

Research shows that inhibiting the mechanically sensitive ion channel PIEZO1 can upregulate the expression of GPX4 by blocking calcium ion influx, effectively inhibit ferroptosis of chondrocytes, and significantly alleviate the pathological damage of OA (Liu et al., 2024)

Pancreatitis There is a known, although rare, risk of acute pancreatitis with GLP-1RAs