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For autoimmune patients, these combination formulations may provide modest additional anti-inflammatory benefit beyond the GLP-1 alone

Because of its structural similarity to other secretagogue peptides, GHRP-6 is often studied alongside compounds such as GHRP-2, CJC-1295, and Ipamorelin in laboratory endocrine research systems

Additionally, presumably due to the high concentration of DPP-4 found on hepatocytes, 4050% of the remaining active GLP-1 is degraded across the liver

Regarding co-agonist treatment, tirzepatide was recently shown in a post hoc analysis of the SURMOUNT-1 trial to also reduce UACR in overweight/obese people without T2D (88), and similar benefits for kidney function were shown in subjects with heart failure (89)