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During clinical trials, individuals on retatrutide experienced an average reduction in body weight between 28.7 percent and 30 percent within 68 weeks

10.1038/onc.2017.38 Summary Keywords alcohol-associated liver disease (ALD), glucagon-like peptide 1 receptor agonists (GLP-1 RAs), metabolic dysfunction and alcohol-associated liver disease (MetALD), metabolic dysfunction-associated steatotic liver disease (MASLD), steatotic liver disease (SLD) Citation Mahalingam S, Kharbanda KK, Casey CA and Rasineni K (2026) Beyond diabetes and obesity: GLP-1 receptor agonists as multifunctional therapeutics across the steatotic liver disease spectrum

Eight percent involve gallbladder complications

Each element is essential for reaching glycemic goals and managing weight-related complications