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doi: 10.1016/S2213-2600(20)30079-5 299 YangJ.ZhengY.GouX.PuK.ChenZ.GuoQ.et al

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Withdrawal symptoms, ranging from a return of uncomfortable psychological symptoms to physical manifestations such as nausea and diarrhea, may occur when the drugs are removed from the bloodstream

Furthermore these receptors have RAMPS or receptor activity modifying proteins, RAMP1 & AMY1 act on fat storage/adiposity, RAMP3 & AMY3 seem to act on eating preference and glucose control