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May 1, 2026: Judge in Ozempic MDL Issues Two Discovery Orders as Number of NAION Claims Approaches 90 There are 86 claims in the multidistrict litigation about whether Ozempic and other GLP-1s caused some patients to develop NAION

Microglial TLR9 stimulation increases production of pro-inflammatory cytokines and chemokines, while astrocytic activation contributes to gliosis and release of neurotoxic mediators

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Notably, potential biomarkers such as 11,12-epoxyeicosatrienoic acid (AUC = 0.964) and MG (PGF2alpha/0:0/0:0) (AUC = 0.953) are implicated in pathophysiological mechanisms of MMA and its standard treatment through their association with inflammation, oxidative stress, and altered fatty acid metabolism