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Front Mol Neurosci 14:665686

This study generated a metabolite model that could predict clinical outcomes, quantified by Therapy Intensity Level (TIL), in the initial and validation cohorts based on the levels of the ketogenic AA isoleucine, ketone bodies (-hydroxybutyrate and acetoacetate), medium chain fatty acids (dodecanoic acid, suberic acid, 2-hydroxyoctanoic acid), medium chain fatty acid derivatives (10-hydroxydecanoic acid, 8-hydroxyoctanoic acid), and butyrylcarnitine (Table 2) [46]

Cumulatively, semaglutide alone accounts for hundreds of thousands of patient-years of exposure across trials and real-world use [20]