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Yee KK, Sukumaran SK, Kotha R, Gilbertson TA, Margolskee RF

This is the proposed mechanism by which oxidative stress initiates and amplifies autoimmune thyroid disease: oxidized thyroid proteins immune recognition TPO antibodies (TPOAb) and thyroglobulin antibodies (TgAb) progressive thyroid destruction

The 28-day guideline is based on pharmaceutical stability studies that determine the length of time the preservative can reliably maintain sterility through multiple punctures

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