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Finally, A1AT antioxidant properties can neutralize reactive oxygen species (ROS), reducing oxidative stress that contributes to both beta-cell dysfunction and insulin resistance

Appl Environ Microbiol 70:19131922 Aydin S, Yargicoglu P, Derin N, Aliciguzel Y, Abidin I, Agar A (2005) The effect of chronic restraint stress and sulfite on visual evoked potentials (VEPs): relation to lipid peroxidation

Zhao Z, Hu Z, Zeng R, Yao Y

Altogether, although metformin can activate AMPK, it is therefore neither necessary nor sufficient for inducing acute inhibition of gluconeogenesis (Figure 1)