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Popular STZ and high-fat/STZ models can recapitulate hyperglycemia and early neuropathic abnormalities but do not recapitulate chronic axonal loss, small-fibre degeneration, and comorbidities typical of protracted diabetic neuropathy

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Following this exploratory 12-week pilot study, a randomised, double-blind trial with direct or indirect intracranial pressure measurement is now being planned by the same research team in Naples, led by professor Roberto De Simone