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Briefly, the preproglucagon gene undergoes tissue-specific post-translational modification with the help of specific propeptidase convertase (PC1/3) to produce two variants of GLP-1, the amidated GLP-1 [736], and the glycine-extended GLP-1 [737] in the ileum and hypothalamus (Lafferty et al., 2021

Complex analysis of single-cell RNA sequencing data

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Cardiovascular protective effect of metformin and telmisartan: reduction of PARP1 activity via the AMPK-PARP1 cascade