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323 In addition to the above two drugs, asparaginase-targeting drugs include OP-01, JZP-458, ERY-001, and PF-690

These findings offer a new therapeutic strategy for this rare, aggressive malignancy and warrant further investigation in larger cohorts

The study quantified cytokines, neurotransmitters, oxidative stress markers and detoxification enzymes using ELISA-based assays, revealing that VPA exposure disrupted glutathione balance, increased IL-6, CYP450 and glutamate, and reduced serotonin and IFN-, while curcumin partially restored these alterations ( Furthermore, Yang and Bhandari employed a PPA-induced rat model of autism, using male-only Sprague-Dawley rats that received intracerebroventricular infusions of 1M PPA

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