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Nature 408 , 255262 (2000)

The difference comes down to bioavailability and understanding that variable is the key to setting realistic expectations

Research in this area examines both subjective desire and physiological arousal markers in response to MC4R pathway activation

and (3) enhanced repeated Wingate outcomes (total work done over 4 Wingate tests) in both trained and untrained subjects (de Salles Painelli et al., 2014)