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As mentioned above, within the IMM, cytochrome c participates in the mitochondrial ETC, using its heme group as a redox intermediate to shuttle electrons between complex III and complex IV
Currently, AQ is forbidden for prophylactic use and is only prescribed in combination therapy with artesunate, as recommended by WHO (2015)
Major secondary outcome was change in serum vascular endothelial growth factor (VEGF), angiopoietin like protein 2 (ANGPTL2), angiopoietin like protein 4 (ANGPTL4), and adrenomedullin levels from baseline to 24 weeks
All prescribing decisions are made by the evaluating provider
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