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However, through histological examinations by Ramn y Cajal, a 20 to 40 nm gap between neurons, known today as the synaptic cleft, was discovered

This embedding is made possible by the fact that the poly(lactic acid) core of the PEG-PLA NPs within the hydrogel structure is hydrophobic in nature and the HPMC-C 12 polymers possess hydrophobic moieties, both of which act as sites for robust non-covalent, hydrophobic interactions between the drug molecules and the hydrogel components