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In accordance with this, aging-associated immunologic alterations comprise reduced pathogenic resilience, impaired development of long-term immune memory and declined vaccine efficacy, alongside an increased susceptibility to viral infections with exacerbated symptoms and an overall deteriorated etiopathology, as this heightened vulnerability of older people, especially of those with comorbidities, has been highlighted by the recent coronavirus disease 2019 (COVID-19) pandemic [7, 32,33,34]

Hence, we mutated these 2K to R, which mimicked the deubiquitination of the protein