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Description

The future question is mechanism, durability, and clinical governance

10f,g), as well as a substantially lower EC 50 in the FP assay (Fig

The mechanism is not cosmetic it is structural

Increased deacetylation and activation of the master gluconeogenic transcription factor forkhead box protein O1 by NAD-dependent protein deacetylase sirtuin 1 is also stimulated by T3 leading to increase in gluconeogenesis