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| Atributo | Retatrutida | Tirzepatida | Semaglutida | |---|---|---|---| | Receptores | GLP-1 + GIP + GCG | GLP-1 + GIP | GLP-1 | | Vida media estimada | ~6 das | ~5 das | ~7 das | | Va estudiada | Subcutnea semanal | Subcutnea semanal | Subcutnea / oral | | Reduccin ponderal fase 2 | Hasta 24.2% | Hasta 22.5% | Hasta 15-17% | | Componente termognico | S (GCG-R) | No | No | Historia y desarrollo Retatrutida (cdigo LY3437943) fue desarrollada por Eli Lilly and Company como evolucin del programa incretnico que dio origen a dulaglutida (mono-GLP-1) y tirzepatida (dual GLP-1/GIP, comercializada como Zepbound)

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