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A small clinical study tested whether a 24-hour fast or moderate exercise affected THC levels in chronic cannabis consumers and found no meaningful change in blood or urine levels

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53,54 However, it has also been suggested that the enhanced release of proinflammatory cytokines (TNF-, IL-1, IL-6, and IL-10) and chemokines (monocyte chemoattractant protein-1, macrophage inflammatory protein-2, and IL-8) further promotes hepatocyte damage, thereby aggravating necrosis

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