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Reactive nitrogen species (RNS) have been reported to play an important role in beta cell fate, function and viability and NO mediates intra-islet cytokine signalling pathways [33]

Insulin-sensitizing drugs are the second-line treatment, with metformin being the most recommended therapeutic option, to improve peripheral insulin sensitivity in order to decrease insulin levels and, consequently, insulin-mediated stimulation of ovarian androgen secretion 17

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