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Free Cu2+ is toxic (Fenton reactions, hydroxyl radicals), but the GHK-Cu complex is stable, diffusible and delivers copper in a targeted manner to copper-dependent metalloenzymes: lysyl oxidase (collagen/elastin crosslinking), Cu/Zn superoxide dismutase (SOD1, antioxidant defence), tyrosinase (controlled melanogenesis), dopamine-beta-hydroxylase
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Some fatty acids with multiple methyl branches, e.g., those derived from phytol such as phytanic acid, are not amenable to oxidation, but they can be degraded by oxidation in peroxisomes
If their insulin dose has not been adjusted to account for the ongoing insulin-sensitizing effect, they may experience hypoglycemia well after the exercise session ends
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