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36 To experimentally validate this causal link, we employed a GAN diet-induced nutritional model and genetically obese leptin-deficient ( ob / ob ) mice (Fig

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Taking these findings into account, along with the elevated subclinical gut inflammation and intestinal permeability observed during earlier studies involving patients with rheumatic disease, it can be proposed that gut-joint communication plays an important role in AD development (Mielants et al