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No matter what we've done, we've not been able to nail precisely why they are resistant." The team concentrated on two genetic variants that reduce the activity of an enzyme called PAM (peptidyl-glycine alpha-amidating monooxygenase)

Lawrance R, Degtyarev E, Griffiths P et al (2020) What is an estimand & how does it relate to quantifying the effect of treatment on patient-reported quality of life outcomes in clinical trials