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Upregulated expression of these two transporters can significantly accelerate the efflux of platinum agents from cells and reduce intracellular platinum accumulation, which not only impairs anti-tumor efficacy and mediates chemotherapy resistance, but also affects cumulative toxicity by altering the tissue distribution profile of the agents

Curr Res Green Sustain Chem 4:100055 Zakaria MR et al (2023) Production of biochar and activated carbon from oil palm biomass: current status, prospects, and challenges

It regulates numerous genes associated with ferroptosis, including those involved in GSH synthesis, NADPH regeneration, and iron metabolism (such as iron storage and export, as well as heme synthesis and degradation)

On the other hand, resisting cell death is a well-known hallmark of cancer [416]