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The WD40 co-crystal structures with the wild-type and clientized Thr127Glu S heptapeptides were determined to a resolution of 1.4 (Supplementary Table S3)

When results stay slow or disappointing, it becomes important to find a treatment that works at a deeper level

Molecular modeling of the proposed JAK2 trans -inhibition interaction of the PKD with the KD placed the V617F in proximity to the activation loop of the KD