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Washington, DC: The National Academies Press, 2014

MOTS-c and NAD+ work differently but overlap in one key area: MOTS-c increases cellular NAD+ levels as part of its mechanism, which means stacking both compounds can create a synergistic effect rather than a redundant one

The Clinical Data: Everything Published So Far Phase 1 First-in-Human (Oral Formulation) Published: The Lancet, June 2025 Participants: 144 adults with overweight or obesity (BMI 25.039.9), no diabetes Duration: Up to 12 weeks Dosing: Once-daily oral amycretin, up to 2 50 mg Results: - 50 mg dose: 10.4% mean body weight change - 2 50 mg dose: 13.1% mean body weight change - Placebo: 1.2% 13% weight loss in 12 weeks

mechanistic and exploratory, not a clinical efficacy trial