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Studies using GHRH antagonists showed that blocking hypothalamic GHRH largely eliminated the growth hormone response to GHRP-6

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Enrichment analysis using Metascape also identified 10 DEPs involved in mitochondrial organization (i.e., 4 and 6 were up- and downregulated, respectively, after HC treatment) (Figure 5D) with a downregulation, for example, of AKT1, TOMM20 (translocase of the outer mitochondrial membrane 20), and RRM2B (Ribonucleotide Reductase Regulatory TP53 Inducible Subunit M2B), and an upregulation of MTFR1 (mitochondrial fission regulator 1) and MIEF1 (mitochondrial elongation factor 1)