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Dose-response data shows a logarithmic curve: increasing dose from 20 mcg to 30 mcg produces meaningful improvement in recovery velocity, but increasing from 40 mcg to 60 mcg produces no additional benefit while doubling side effect incidence

A boy his age drowned in an accident

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trials used a stepwise dose-escalation approach at Q4W In TRIUMPH-3, 12mg reduced TGs, non-HDL cholesterol, systolic BP, waist circumference, & hsCRP by 37%, 16.5%, 9.3mmHg, 19cm, & 51.2%, respectively