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The association of genetically predicted l-carnitine with CAD in men not in women is possibly due to a smaller number of CAD cases in women therefore a lower power (as shown in Additional file 1: Table S6)
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The CLOCK/BMAL1 heterodimer combines with the E-box response element which located in the promoter region to stimulate the expression of other target genes, the core of which is the transcriptional expression of other clock genes, such as Periods ( PER1 , PER2 , and PER3 ), and Cryptochromes ( CRY1 and CRY2 )
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