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3 COMT inhibitors, such as entacapone, opicapone, and tolcapone, and MAO-B inhibitors, such as selegiline, rasagiline, and safinamide, work by enhancing levodopas duration of action with inhibition of their respective enzymes

98 It leads to the weakening of the ability of renal cells to clear damaged proteins and organelles, thus promoting renal fibrosis in DR

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