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Aggregates can change pharmacological behaviour, reduce effective bioavailability or contribute to antibody formation
Gastroenterology 132: 17671777
This creates a risk of: Contamination with undisclosed active substances Inaccurate labelling , meaning the product may contain more or less of a compound than stated Adulteration with pharmaceutical agents, including stimulants or diuretics, which have been identified in some weight loss supplements by the MHRA Even where peptide compounds are genuine, oral bioavailability is a fundamental pharmacological challenge
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