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Rose et al 2023 demonstrated that certain chemotherapeutic drugs such as talazoparib, camptothecin and etoposide binds and traps proteins (PARP and topoisomerases I and II, respectively) on DNA strands, resulting in DNA damage and double-strand breaks

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Its vertically measured in millimeters from the top of the superficial ulceration (granular layer) to the deepest point of tumor involvement