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FDA prescribing information for some GLP-1 receptor agonists (particularly those approved for weight management) includes recommendations to monitor heart rate at regular intervals and consider discontinuation for sustained increases in resting heart rate

Even the most affordable option, Byetta, becomes costlier than surgery after around 1.5 years

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Role of -cell Produced Gcg in Insulin Secretion -Cell GLP-1 during metabolic stress PC1/3, which processes GLP-1 (and GLP-2 and oxyntomodulin) from Gcg , is more predominantly expressed in the gut and CNS, but -cell PC1/3 activity and/or expression is found in embryonic and neonatal mice, with pregnancy, and in models of prediabetes and diabetes (118, 172, 224, 245)