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Going very grey before the age of 30 is considered premature greying and is most often a sign of a deficiency in a key vitamin or mineral, particularly a lack of B-vitamins, or low calcium or iron, although it can also be a symptom of rare genetic disorders

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42 A double-blind crossover study from 1973 in patients complaining of tiredness found benefits of hydroxo-B12, 5000 g twice per week i.m

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