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A cohort study revealed an increased risk of pancreatitis, and 36% of patients who used GLP-1 RAs or DPP- 4 inhibitors had elevated serum amylase or lipase (or both) levels compared with 18% of patients not taking these agents ( Our studies showed GLP-1 RA-associated gastrointestinal toxicities occurred 30 days (3,234, 77.44%) after the initiation of GLP-1RAs, and the median time-to-onset was 1 (IQR 024) days with a significant difference between different GLP-1 RA regimens

While microdosing GLP-1s may be beneficial for a variety of reasons for certain individuals, the growing interest in microdosing GLP-1s can at least in part be tied to the significant metabolic shifts women experience during perimenopause and menopause

Symptomatic improvement often precedes laboratory normalisation

doi:10.2337/db14-0849 Vilsbll T, Holst JJ