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In atopic dermatitis mouse models, AES16-2M administration downregulated disease scores, ear thickness, serum IgE (a key marker of allergic disease), and TSLP

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In terms of kinase enrichment, pathways related to cell cycle, DNA damage response, cell proliferation and regulation of cytoskeleton organization account for the effects of (M+D)/2 and (M+D+V)/3 compared to the addition of single agents (LIMK1, TESK1, P70S6K, CDK1, CDK2, CAMK4, CAMK2B) ( Figures 7C, D )