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Yes, but theres no pharmacological rationale for combining them both activate overlapping melanocortin receptors (MC3R and MC4R), so co-administration simply increases the total agonist exposure without adding mechanistic diversity

Table 2 Development studies with five DPP-4 inhibitors: number of examined subjects and placebo-adjusted change in HA1c when DPP-4 inhibitors were added to drug-nave subjects with type 2 diabetes or as add-on to metformin, sulfonylurea, thiazolidinediones, or insulin in placebo-controlled 24 or 26 week studies

Healthcare providers can then decide if tests or further evaluations are needed

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