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Wang et al., 2021a

Contrave is indicated for chronic weight management in adults with a body mass index (BMI) of 30 kg/m2 or more (obese) or 27 kg/m2 or more (overweight) with at least one other weight-related risk factor, such as high blood pressure, Type 2 diabetes, or high cholesterol

In the process of practical application, researchers should understand the species differences between experimental animals and human beings, the formation mechanism of MASLD model and pathological changes are very different from those of human beings when they suffer from the disease and they need to select appropriate models according to specific research purposes and needs and consider the complications of the MASLD model

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