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Signs you should slow down the titration Extend your stay at the current dose by 2-4 additional weeks if you experience any of the following at the end of a standard 4-week period: Nausea persisting beyond the first 7 days after the last dose increase Vomiting more than twice per week Diarrhea lasting more than 10 days at the current dose Significant fatigue or weakness that does not improve with adequate nutrition and rest Weight loss exceeding 1.5% per week (too-rapid loss increases gallstone risk and muscle loss) Slowing the titration is not failure

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At 8mg specifically, 100% of participants lost at least 5% of their body weight, 91% lost at least 10%, and 75% lost at least 15%

[1] Alternative Options When GLP-1 Treatment Fails When GLP-1 medications prove ineffective despite optimisation, several alternative therapeutic strategies exist, depending on whether the primary goal is diabetes management or weight loss