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The results of one population-based cohort study, designed to emulate a randomised controlled trial, suggest that the combined use of GLP-1RAs and SGLT-2is is associated with a reduced risk of major adverse CV events and serious kidney events, compared with using either drug class alone

But biologically, many of these conditions share overlapping drivers: chronic inflammation immune dysregulation insulin resistance altered brain reward signaling mitochondrial stress hormone imbalance GLP-1s may be effective for so many different conditions because they target shared biological pathways that contribute to many age-related and inflammation-linked conditions

Leptin deficiency causes insulin resistance induced by uncontrolled diabetes

doi: 10.1016/S1079-2104(97)90318-8