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Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23

These findings tightly link ROS and Nrf2 to ER oxidative protein folding and calcium signaling, establishing a regulatory mechanism for protein oxidative folding-Nrf2-ER calcium axis (Figure 7)

9 While there is an established association between statin therapy and liver injury, it is important to rule out other causes of liver injury

As awareness and adoption of GLP-1 therapies increase, especially among first-time users, the demand for low-dose formulations is likely to rise