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Rett syndrome, caused by MECP2 gene mutations, disrupts GABAergic interneuron development, lowering GABA concentrations in the hippocampus and prefrontal cortex, leading to developmental regression, such as loss of language and motor skills, and stereotypic hand movements like hand-wringing (77)

Studies have shown that methylene blue can enhance cognitive functions and decrease the buildup of beta-amyloid plaques in Alzheimers patients, offering hope for a therapeutic breakthrough

doi: 10.3389/fcell.2025.1619758 Received 28 April 2025 Accepted 13 June 2025 Published 26 June 2025 Volume 13 - 2025 Edited by Marcela Alejandra Michaut, CONICET Dr