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In all the studies, the combined therapy was superior to other diabetes treatment options or each medication separately in reducing HbA1c and weight

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However, 15% to 20% of ER+ tumors are intrinsically resistant to endocrine treatment while 30% to 40% of ER+ tumors develop endocrine resistance to this class of drugs throughout treatment [9, 10]

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Two types of vitamin B12 injections are usually given hydroxocobalamin and cyanocobalamin

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