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These models may not fully recapitulate the chronic, multifactorial nature of human ocular diseases like DR, which involves decades of metabolic dysregulation and low-grade inflammation [130,131,132,133]

Careful consideration of potential benefits and risks is essential for optimizing treatment outcomes and ensuring patient safety when using GLP-1 RAs in clinical practice

A higher degree of inflammation was verified in groups IH1 to IH3 (IH period of 1.5% O 2 for 15 s followed by reoxygenation periods of 21% O 2 for 8 min and 15 s, 5 min and 15 s, and 3 min and 45 s, respectively)

Incorporating insights from experts like Dr