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This has been demonstrated in the NOD.H2 h4 mouse model of autoimmune thyroiditis where iodide treatment enhanced the transcription of intercellular adhesion molecule-1 triggered by reactive oxygen species and, in particular, by hydrogen peroxide generated in the thyrocyte for the organification of iodine ( Reference Burek and Talor 26 , Reference Sharma, Traore and Trush 27 )