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To prolong plasma half-life and improve drug delivery, butyrate and sorafenib were co-encapsulated within antibody-functionalized mPEG-PLGA-PLL nanoparticles, which significantly reduced sorafenib-induced liver injury and suppressed hepatocellular carcinoma progression [121]

Aberrant DNA methylation patterns have been identified in patients with HT, leading to gene silencing and altered expression of genes regulating the immune response, along with hypermethylation of specific CpG sites

The percentage of patients who achieved a clinically meaningful treatment response (defined as achieving at least 5% weight loss after 1 year of treatment) ranged from 36% to 57% with CONTRAVE, compared to 17% to 43% with placebo

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