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Types and profiles of basal insulin Recommendation 2: Review concomitant T2DM medications when starting basal insulin and continue them at the current or lower dose where appropriate

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Seiwerth and colleagues (Inflammopharmacology, 1999) documented effects on angiogenic growth factor pathway signalling, and subsequent work has expanded characterisation to include VEGF receptor 2 upregulation, endothelial cell migration in capillary-formation assays, and improved healing in ischemia-reperfusion preparations