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High-dose intravenous vitamin C holds the second position in this ranking because its evidence base is simultaneously among the broadest and most mechanistically precise of any longevity IV intervention

However, several things can inhibit the secretion of intrinsic factors, which in turn decreases the absorption of B12 by around half per dose, regardless of how high the overall dosage level is given

A recent small study of healthy older adults given glyNAC, a supplement that increases glutathione levels, showed lower oxidative stress and inflammation after 24 weeks of treatment (10)

But oral glutathione at the same dose showed no statistically significant benefit