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Switching from Saxenda to Retatrutide: Clinical Considerations Why Patients Switch Patients typically consider switching when they have plateaued on liraglutide 3 mg after at least 16 weeks at maintenance dose, when they find daily injections burdensome relative to a once-weekly option, or when emerging data on triple agonism suggests the ceiling of GLP-1 monotherapy has been reached for their biology

Kidney Problems Some patients, particularly those prone to dehydration due to vomiting or diarrhea, may experience kidney issues

Skeletal Muscle Facilitates glucose uptake Stimulates glycogen synthesis Supports metabolic flexibility Muscle insulin resistance significantly reduces whole-body glucose disposal

Magnetic resonance imaging of the spine may be necessary to evaluate for a tethered cord, spinal cord tumor, or sacral agenesis