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In summary, while structurally similar dimethylxanthines have different physiological effects, the impact of theophylline and theobromine on cognition is generally less pronounced than that of caffeine and paraxanthine

Insulin and insulin-like growth factors I and II (IGF-I and IGF-II) are critical for neuronal and glial growth, metabolic regulation, survival, gene expression, protein synthesis, neurotransmitter network modulation, and synaptic function